Status:
TERMINATED
Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer Patients
Lead Sponsor:
British Columbia Cancer Agency
Conditions:
Constipation
Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This is a study to compare the efficacy and tolerability of two laxatives for treatment of opioid-induced constipation in adult outpatients with cancer treated at the British Columbia Cancer Pain and ...
Detailed Description
One group will be started on a bowel protocol of escalating doses of sennosides, plus a dummy polyethylene glycol (lactose), and the other will receive dummy sennosides capsules (lactose) plus polyeth...
Eligibility Criteria
Inclusion
- Adult patient (18 years and above) with diagnosis of cancer.
- Patient requires treatment or prevention of constipation.
- Patient is able to communicate effectively with staff.
- Expected prognosis more than 12 weeks.
- On or starting opioid therapy
Exclusion
- Patient unable to take oral medication.
- Allergy or previous intolerance to PEG or sennosides.
- Lactose intolerant.
- Contraindication to PEG or sennosides.
- Known or suspected bowel obstruction or ileus.
- Colostomy or ileostomy.
- Inflammatory bowel disease.
- Hospitalisation expected within the study period.
- Patient unable to complete the study diary in English.
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT01189409
Start Date
June 1 2010
End Date
October 1 2018
Last Update
August 28 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
BC Cancer Agency
Vancouver, British Columbia, Canada, V5Z 4E6