Status:
COMPLETED
Normothermic Ex Vivo Lung Perfusion (EVLP) For An Improved Assessment of Donor Lungs For Transplantation
Lead Sponsor:
XVIVO Perfusion
Conditions:
Lung Transplantation
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The use of ex vivo lung perfusion (EVLP) will allow for a secondary evaluation technique for donor lungs that fail to meet standard acceptability criteria. This advanced assessment might lead to incre...
Detailed Description
Human donor lungs that do not meet the standard clinical criteria for donor lung utilization but fit into the study inclusion criteria will be retrieved from the donor using current donor lung retriev...
Eligibility Criteria
Inclusion
- Inclusion Criteria for donor lung:
- Recipient to undergo a single or bilateral Lung Transplantation
- Last donor PaO2/FiO2 ≤ 300mmHg
- Poor oxygenation and/or poor lung compliance is the primary reason for unsuitability
- Absence of pneumonia, persistent purulent secretion on bronchoscopy or significant mechanical trauma
- Exclusion Criteria:
- Infection
- Aspiration
- Significant mechanical lung injury - contusion
- Infectious diseases : HIV, Hepatitis B and C, HTLV \& Syphilis
- Malignancy
Exclusion
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT01190059
Start Date
August 1 2008
End Date
February 1 2010
Last Update
April 4 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Toronto General Hospital
Toronto, Ontario, Canada, M5G 1Z5