Status:
COMPLETED
Dose-ranging Study of Tranexamic Acid in Valve Surgery
Lead Sponsor:
Chinese Academy of Medical Sciences, Fuwai Hospital
Conditions:
Hemorrhage
Valvular Heart Surgery
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Cardiac surgical procedures account for a large amount of allogeneic transfusion. Tranexamic acid (TA), a synthetic antifibrinolytic drug, has been shown to reduce blood loss and transfusion requireme...
Eligibility Criteria
Inclusion
- valvular disease patients requiring valvular replacement or repair surgery with cardiopulmonary bypass (CPB)
Exclusion
- a history of bleeding disorders
- active chronic hepatitis or cirrhosis
- chronic renal insufficiency (serum creatinine \> 2 mg/dl)
- preoperative anemia (Hb \< 10 g/dl)
- previous cardiac surgery
- urgent and emergency surgery
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT01191554
Start Date
September 1 2010
End Date
October 1 2011
Last Update
November 6 2012
Active Locations (1)
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1
Cardiovascular Institute and Fuwai Hospital
Beijing, China, 100037