Status:
COMPLETED
Opioid Effects on Swallowing and Esophageal Sphincter Pressure
Lead Sponsor:
Region Örebro County
Conditions:
Opioid Induced Pharyngeal and Esophageal Dysfunction
Eligibility:
All Genders
18-40 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether a dopamine receptor antagonist metoclopramide can counteract opioid induced effects on esophageal motility and lower esophageal sphincter. The aim of ...
Detailed Description
Opioids induce pharyngeal and esophageal dysfunction and reduce the lower esophageal sphincter (LES) pressure, and thereby decreases the barrier pressure between the stomach and esophagus. This contri...
Eligibility Criteria
Inclusion
- 18 - 40 year old healthy volunteers from both sexes.
- Have signed and dated Informed Consent.
- Willing and able to comply with the protocol for the duration of the trial.
Exclusion
- Anamnesis of pharyngoesophageal dysfunction
- Known history of cardiac, pulmonary or neurological disease
- Ongoing medication
- Allergies to or history of reaction to naloxone, remifentanil, fentanyl analogues or metoclopramide
- Pregnancy or breast feeding
- BMI \> 30
- Previous participation in a medical clinical trial where opioid has been used or have during last 30 days participated in any other medicinal clinical trial or in a trial where follow-up in not completed.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT01191645
Start Date
October 1 2010
End Date
November 1 2010
Last Update
February 2 2012
Active Locations (1)
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1
Örebro University Hospital
Örebro, Sweden, 70185