Status:
COMPLETED
A Study of PNT2258 in Patients With Advanced Solid Tumors
Lead Sponsor:
Sierra Oncology LLC - a GSK company
Conditions:
Cancer
Lymphoma
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This study is sponsored by Sierra Oncology, Inc. formerly ProNAi Therapeutics, Inc. The purpose of this research study is to evaluate the safety of the investigational drug PNT2258 in patients with ad...
Detailed Description
This study is an open-label, single-arm, Phase 1 dose-escalation study of PNT2258 in patients with advanced solid tumors for which no standard therapy exists. Patients will receive PNT2258 as an intra...
Eligibility Criteria
Inclusion
- Histologically confirmed, malignant solid tumor (measurable or non-measurable disease) and cannot be a candidate for known regimens or protocol treatments of higher efficacy or priority.
- Recovered to Grade 1 from all acute toxicities of prior therapies, except for residual toxicities, such as alopecia, which do not pose an ongoing medical risk.
- ECOG performance status of 0, 1, or 2.
- At least 18 years of age.
- Patients must have normal organ and marrow function as defined by:
- Absolute neutrophil count 1,500/µL
- Platelets 100,000/µL
- Total bilirubin within normal institutional limits
- AST(SGOT)/ALT(SGPT) 2.5 x institutional upper limit of normal (ULN) or 5.0 x ULN in patients with liver metastases
- Serum creatinine 1.5 x ULN or measured creatinine clearance of 60 mL/min/1.73 m2.
- Negative serum pregnancy test at the time of enrollment for women of child-bearing potential. For men and women of child-producing potential, use of effective contraceptive methods is required during the study.
- Ability to understand the requirements of the study. Must provide written informed consent and authorization of use and disclosure of protected health information. Must agree to abide by the study restrictions and to return for the required assessments.
Exclusion
- Received previous anticancer chemotherapy, immunotherapy, radiotherapy or any other investigational therapy in the 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to study entry.
- Receiving any other investigational agents.
- Known brain metastases with the exception of patients with a history of treated brain metastases who are stable for at least 3 months off glucocorticoids and seizure medications.
- Prolongation of QT/QTc interval \> 450 milliseconds (ms).
- Known HIV, HBV, or HCV infection.
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to PNT2258.
- History of allergic reaction to egg or chicken antigens.
- Pregnant or nursing women.
- Uncontrolled intercurrent illness including, but not limited to ongoing or serious active infection, symptomatic congestive heart failure, unstable angina pectoris, serious cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT01191775
Start Date
August 1 2010
End Date
April 1 2012
Last Update
April 19 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
South Texas Accelerated Research Therapeutics (START)
San Antonio, Texas, United States, 78229