Status:
COMPLETED
TachoSil® Versus Surgicel® Original for the Secondary Treatment of Local Bleeding in Adult and Pediatric Patients Undergoing Hepatic Resection Surgery
Lead Sponsor:
Takeda
Conditions:
Hemorrhage
Eligibility:
All Genders
Phase:
PHASE3
Brief Summary
The efficacy and safety of TachoSil® as secondary hemostatic treatment in hepatic resection surgery will be compared to the standard USA licensed hemostatic agent, Surgicel® Original. Hemostatic effic...
Eligibility Criteria
Inclusion
- Resection of at least the equivalent tissue volume of 1 anatomical segment of the liver
- Minor to moderate (oozing/diffuse) bleeding from the resection area persisting after conventional resection procedure and primary control of arterial pulsating bleeding or major venous hemorrhage by sutures, ligations, clips, vascular stapler, point electrocautery or focal radiofrequency ablation
- Need for additional supportive hemostatic treatment
- Expected ability to lightly press the trial treatment to the liver resection wound for 3 minutes
Exclusion
- Indication for emergency surgery
- Known coagulopathy (as judged relevant by the investigator)
- Known or suspected hypersensitivity to any ingredient of the investigational medicinal products (e.g. human fibrinogen, human thrombin and/or collagen of any origin)
- Patient unwilling to receive blood products
- Known current alcohol or drug abuse
- Pregnancy, breastfeeding, no use of acceptable contraceptive method in females of childbearing potential
- Dry surgical field of the targeted application area
- Occurrence of any serious surgical complication
- Disseminated intravascular coagulopathy (DIC), i.e. microvascular bleeding
- Application of topical hemostatic material on the liver resection wound
- Radiofrequency precoagulation of the liver resection wound except focal radiofrequency ablation of vessels as primary hemostatic treatment
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
253 Patients enrolled
Trial Details
Trial ID
NCT01192022
Start Date
August 1 2010
End Date
May 1 2013
Last Update
November 25 2015
Active Locations (17)
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1
Los Angeles, California, United States
2
Washington D.C., District of Columbia, United States
3
Chicago, Illinois, United States
4
Louisville, Kentucky, United States