Status:
COMPLETED
Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung Disease
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Heart Disease
Cystic Fibrosis
Eligibility:
All Genders
6+ years
Phase:
PHASE3
Brief Summary
The primary objective of this study is to determine if quantitative Dynamic contrast-enhanced magnetic resonance (DCE MR) perfusion imaging accurately quantifies right and left pulmonary artery blood ...
Detailed Description
Many conditions of the heart or the lungs lead to differences in how the blood is pumped to the lungs. Specifically, some areas of the lung may receive less blood supply than others. We would like to ...
Eligibility Criteria
Inclusion
- Cardiac Patients:
- Patients \> 6 years of age
- Patients with suspected or confirmed congenital or acquired heart disease
- Who undergo a clinically indicated MRI scan, including gadolinium (MRI contrast medium)
- And receive gadolinium (= MRI contrast medium) as part of their clinical investigation
- Pulmonary Patients:
- Patients \> 6 years of age
- Patients with a chronic and stable lung condition, such as cystic fibrosis, severe asthma.
Exclusion
- Children under the age of 6 will be excluded as they are routinely scanned under general anesthesia
- Patients in whom MRI is contraindicated (e.g. pacemaker, ocular metal, claustrophobia, tattoos)
- Patients with a known allergy to gadolinium.
- Patients with a history of allergic disposition or have anaphylactic reactions
- Moderate-to-severe renal impairment (defined as having a GFR/ eGFR \< 60 mL/min)
- Have Sickle Cell anemia
- Known pregnancy, or breast feeding
- Patient is uncooperative during a MRI without sedation or anesthesia
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT01192360
Start Date
September 1 2010
End Date
December 1 2012
Last Update
July 5 2019
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8