Status:
COMPLETED
A Study on the Effects of a Single Dose of Prednisone on Biomarkers of Allergen Responses in Asthmatics (MK-0000-175)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Asthma
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to evaluate the relationship between upper and lower airway allergen-induced cytokine responses in mild asthmatics by attempting to demonstrate the following: 1) a positiv...
Eligibility Criteria
Inclusion
- Has a clinical history of mild to moderate asthma for at least 6 months, but otherwise is in good health
- Participant with allergic rhinitis and asthma has a history of nonseasonal airway symptoms in response to aeroallergens OR has seasonal symptoms but can be evaluated out-of-season
- Is clinically stable and free of respiratory infection or change in allergen exposure for at least 4 weeks prior to start of study
Exclusion
- Has intolerance to the study drug, inhaled salbutamol, antihistamines, or any other potential asthma/anaphylaxis rescue medication
- Has intolerance to lidocaine/lignocaine, sedatives, atropine or glycopyrrolate, or any other medication associated with bronchoscopy
- Has taken oral parenteral corticosteroids within 8 weeks or inhaled corticosteroids/nasal corticosteroids within 5 weeks of screening and/or during the study
- Has recent (4 weeks) or ongoing upper or lower respiratory tract infection
- Has active allergic rhinitis at screening
- Has received a vaccination within 3 weeks of screening
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT01193049
Start Date
August 1 2010
End Date
May 1 2011
Last Update
September 4 2015
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