Status:
UNKNOWN
Multicenter Clinical Trial for Adult Ph-negative ALL. Non-intensive But Non-iterruptive Treatment
Lead Sponsor:
National Research Center for Hematology, Russia
Conditions:
Ph-negative Adult Acute Lymphoblastic Leukemia
Eligibility:
All Genders
15-55 years
Phase:
NA
Brief Summary
1. evaluation of blast clearance in b/m after 7 days of prednisolone prephase and the efficacy of its substitution by dexamethasone if blast count is 25% and more 2. feasibility for adults of "no inte...
Detailed Description
1. The blast count in b/m after 7 days of prednisolone \>25% was shown in 64% of patients. The substitution of prednisolone by dexamethasone did not influence survival. 2. "no interruptions" induction...
Eligibility Criteria
Inclusion
- Ph-negative precursors ALL
- age 15-55 years
- nontreated
- Eastern Cooperative Oncology Group criterion status 0-3
Exclusion
- B-mature ALL
- Ph-positivity
- pretreatment
- Eastern Cooperative Oncology Group criterion status 4
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
321 Patients enrolled
Trial Details
Trial ID
NCT01193933
Start Date
November 1 2008
End Date
December 1 2021
Last Update
March 7 2018
Active Locations (1)
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1
Russian Acute Lymphoblastic Leukemia Study group
Moscow, Russia