Status:
COMPLETED
Biology in Patients With Reflux Esophagitis
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
GERD
Eligibility:
All Genders
18+ years
Brief Summary
GERD is a common condition in the western world. In most cases, the diagnostic is established by good response to empiric proton pump inhibitor (PPI) therapy. When the patient symptoms are refractory ...
Eligibility Criteria
Inclusion
- Inclusion Criteria (GERD Cases):
- Male or female
- Ages 18 years or older
- Undergoing EGD as standard of care at Vanderbilt's Digestive Diseases Center
- Esophageal erosion detected at EGD
- Abnormal pH monitoring
- Inclusion Criteria (Controls):
- Male or female
- Ages 18 years or older
- Undergoing EGD as standard of care at Vanderbilt's Digestive Diseases Center
- No complaints or history o heartburn or acid regurgitation
- No erosion at EGD
- Normal pH monitoring
- Exclusion Criteria:
- Less than 18 years of age
- Unable to provide informed consent
- Use of acid suppressive therapy within last 14 days
- known history of Barrett's esophagus, gastric surgery, alcoholism, significant motility condition
- contraindications to biopsy such as taking anticoagulants other than aspirin (coumadin, plavix) or allergies to local anesthetic
Exclusion
Key Trial Info
Start Date :
November 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT01194323
Start Date
November 1 2010
End Date
December 1 2012
Last Update
April 4 2017
Active Locations (1)
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1
Vanderbilt University Digestive Diseases Center
Nashville, Tennessee, United States, 37232