Status:
WITHDRAWN
Facilitating Numerical Processing With Transcranial Stimulation in Developmental Dyscalculia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Cognition Disorder
Brain Mapping
Eligibility:
All Genders
18-50 years
Brief Summary
Background: \- Developmental dyscalculia is a learning disability in which individuals have difficulty learning or comprehending mathematics or other number concepts (such as keeping score during gam...
Detailed Description
Objectives Developmental dyscalculia (DD) is a condition in which subjects cannot process adequately numerical concepts. Performance of arithmetical calculations is associated with fMRI activity in a...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- We will include healthy volunteers and DD subjects who meet the following criteria:
- Age 18 to 50 years
- Able to provide informed consent
- No history of math difficulties as determined by Dyscalculia Screener examination \> upper 50th percentile (healthy volunteers)
- Diagnosed with DD and scored \< lower 25th percentile on Dyscalculia screening test (Developmental Dyscalculia subjects)
- Edinburgh handedness inventory shows a laterality index (LI) \> 75 (dexterity) or LI of less than -75 (left-handedness)
- EXCLUSION CRITERIA:
- We will exclude healthy volunteers and DD subjects if one of the following conditions applies:
- Unable to perform the tasks due to visual problems
- History of seizures or brain tumor
- History of alcohol or drug abuse (defined as the use of a drug for a nontherapeutic effect ) or psychiatric illness such as severe depression
- History of brain surgery
- Drug treatment acting primarily on the central nervous system, which lowers the seizure threshold such as antipsychotic drugs (chlorprozamine, clozapine).
- Pregnancy
Exclusion
Key Trial Info
Start Date :
August 17 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01195961
Start Date
August 17 2010
End Date
July 1 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892