Status:
TERMINATED
Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome
Lead Sponsor:
University Hospital, Grenoble
Collaborating Sponsors:
Centre Hospitalier Universitaire de Saint Etienne
Hospices Civils de Lyon
Conditions:
Decrease of Inflammation of Adipose Tissue
Sleep Apnea Syndrome
Eligibility:
MALE
18-69 years
Phase:
NA
Brief Summary
The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive a...
Detailed Description
Inflammation of adipose tissue will be evaluated by RT-PCR on mRNA of pro and anti-inflammatory cytokines (IL-1, IL-6, IL-4, IL-10, IL-12, RANTES, TNFa, leptin, adiponectin, CD68).
Eligibility Criteria
Inclusion
- Male between 18 and 70 years old
- Apnea Hypopnea Index \> 30/h and \> 5% TST with SaO2 \< 90%
- patients obese (BMI \> 33kg/m2) or non obese (BMI \< 27kg/m2)
Exclusion
- Female
- coronary ischemic disease, past history of CVA
- chronic pulmonary disease measured by arterial gasometry (PaO2 \< 60mmHg and/or PaCO2 \> 45mmHg)
- known hepatic disease
- alcohol consumption \> 3 units/day
- sleepiness considered to be dangerous by the investigator
- patient having an hazardous work regarding to awareness
- patient being under anticoagulant, antiplatelet drug or having an active stent or bleeding disorder
- patient having an inflammatory syndrome (C-reactive Protein \> 10)
- any allergy to local anaesthetics
- chronic muscle pain
- contraindication to MRI
Key Trial Info
Start Date :
October 16 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 16 2017
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01196845
Start Date
October 16 2010
End Date
February 16 2017
Last Update
December 29 2025
Active Locations (1)
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1
University Hospital Grenoble
Grenoble, France, 38000