Status:
COMPLETED
Virtual Histology Findings and Effects of Varying Doses of Atorvastatin Treatment
Lead Sponsor:
Prof. Stephen Lee
Collaborating Sponsors:
Queen Mary Hospital, Hong Kong
Pfizer
Conditions:
Coronary Disease
Ultrasonography, Interventional
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
While statin treatment may induce plaque regression, the effect of statin on plaque composition with varying doses is unknown. This study assessed such effects by volumetric virtual histology intravas...
Detailed Description
Statin therapy, especially at intensive doses, is beneficial in atherosclerotic coronary disease. Detecting subtle plaque regression after statin therapy is difficult by coronary angiogram; intravascu...
Eligibility Criteria
Inclusion
- Patient aged 18 to 85 (not pregnant) requiring percutaneous intervention to coronary stenosis.
- Statin naive patient.
- No history of myocardial infarction. Angina free for at least 8 weeks.
Exclusion
- Any history of previous statin treatment and myocardial infarction
- Current acute coronary syndrome or in cardiogenic shock
- Surgical bypass candidate
- Chronic total occlusion and very tortuous calcified arteries precluding safe IVUS examination.
- Patient refused to give written informed consent.
Key Trial Info
Start Date :
August 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01200056
Start Date
August 1 2007
End Date
June 1 2010
Last Update
February 28 2013
Active Locations (1)
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1
Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hospital Authority
Hong Kong SAR, Hong Kong, China