Status:
WITHDRAWN
Optimizing Ovulation Induction in the Poor Responder
Lead Sponsor:
Duke University
Collaborating Sponsors:
Emory University
Conditions:
IVF Poor Responders
Eligibility:
FEMALE
20-50 years
Phase:
NA
Brief Summary
The purpose of this randomized controlled trial is to compare the efficacy and effect of luteal estradiol and combined oral contraceptive pills (COPC) on follicle recruitment and synchrony in a poor r...
Detailed Description
1. Protocol Title: Optimizing ovulation induction in the poor responder: a randomized controlled trial of luteal phase estradiol verses combined oral contraceptive pill (COCP) on ovarian morpholog...
Eligibility Criteria
Inclusion
- Antral follicle count \< 8
- Antimullerian hormone (AMH) \<1.3
- Follicle stimulating hormone (FSH)\>10
- History of follicular dysynchrony or poor response
Exclusion
- Menopause
- FSH \>40
- Age \> 50
- Contraindication to estradiol or COCP (including pre-existing cardiovascular disease, familial thrombophilia (factor V Leiden), severe hypercholesterolemia, smoker over age 35) Ovulation induction during month of estradiol treatment
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01200537
Start Date
October 1 2010
End Date
October 1 2012
Last Update
November 21 2012
Active Locations (1)
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1
Duke Fertility Center
Durham, North Carolina, United States, 27713