Status:
COMPLETED
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
Lead Sponsor:
University of Nottingham
Conditions:
Quorum Sensing
Prebiotics
Eligibility:
MALE
18-75 years
Phase:
PHASE1
Brief Summary
It has recently been discovered that bacteria are able to communicate using specialised molecules known as Quorum Sensing Signalling Molecules (QSSMs). An accumulation of QSSMs in their surrounding en...
Eligibility Criteria
Inclusion
- Male volunteers
- Age 18-55 years
- Willing to participate and able to give informed consent
- Alcohol abstinence during study
Exclusion
- Smokers/substance abusers
- Individuals with diabetes mellitus
- Oral/Intravenous steroids
- Allergy to azithromycin
- Individuals already taking regular medications/probiotics/nutritional supplements
- Individuals with chronic disease or currently under investigation
- Individuals with ≤3 bowel movements/week
- Individuals with ≥2 bowel movements/day
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01201577
Start Date
October 1 2009
End Date
May 1 2011
Last Update
June 1 2011
Active Locations (1)
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1
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH