Status:
COMPLETED
The Effects of Orange Juice on Insulin Sensitivity and Plasma Lipids
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
Florida Department of Citrus
Conditions:
Insulin Resistance
Obesity
Eligibility:
FEMALE
18-55 years
Phase:
NA
Brief Summary
The aim of this study is primarily to investigate the ability of antioxidants found in orange juice (OJ) to increase the body's sensitivity to the hormone insulin. Overweight or mildly obese women, wh...
Detailed Description
Background: Overweight and mild obesity are associated with insulin resistance and mild elevations in lipid risk factors which are not usually sufficiently abnormal to merit treatment. Such people ar...
Eligibility Criteria
Inclusion
- pre-menopausal or post-menopausal and taking HRT
- BMI 27-35kg/m2
- HOMA-IR value \> 1.5
- healthy
Exclusion
- pregnant or breast feeding,
- any metabolic or endocrine abnormalities,
- clinically significant abnormalities on screening,
- fasting glucose \> 6.0mmol/l,
- taking medication other than the contraceptive pill or HRT
- herbal supplement use,
- food allergies/intolerances related to the investigational product (citrus juices, fructose)
- daily consumption of \>100ml citrus juices
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01201603
Start Date
July 1 2010
End Date
November 1 2013
Last Update
November 28 2025
Active Locations (1)
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1
University of Nottingham
Nottingham, Notts, United Kingdom, NG7 2UH