Status:
UNKNOWN
Effect of Allergen Challenge on Inflammation Induced by Toll-like Receptor Stimulation in a Nasal Model
Lead Sponsor:
McMaster University
Collaborating Sponsors:
St. Joseph's Healthcare Hamilton
Conditions:
Asthma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Asthma is one of the most common diseases affecting about 2.5 million Canadians, and can result in reduced quality of life and difficulties with work and school. Once the disease has become establishe...
Eligibility Criteria
Inclusion
- 1 Subjects over the age of 18 2 Subjects able to give written informed consent 3 Subjects able to comply with study procedures and protocol 4 Subjects with a history of allergic asthma 5 Subjects with a positive skin prick test to a common aeroallergen 6 Subjects who are otherwise healthy with no other health problems
Exclusion
- Subjects with a viral URTI within 2 weeks prior to screening.
- Subjects with a TNSS\> 2 at screening
- Subjects with a structural nasal abnormality or nasal polyps on examination, a history of frequent nose bleeding, nasal surgery within the previous 3 months.
- Subjects who are a current smoker or have a history of smoking within the previous 3 months.
- Subjects who have used a medication that could affect responses to nasal challenge (eg corticosteroids, decongestants, anti-histamines) or any other nasally applied medication within 2 weeks prior to screening.
- Subjects who have participated in any other clinical trials within the previous 3 months.
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Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01204060
Start Date
September 1 2010
End Date
September 1 2013
Last Update
November 1 2012
Active Locations (1)
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1
St Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8N 4A6