Status:
COMPLETED
Systemic Methylprednisolone in Chronic Rhinosinusitis
Lead Sponsor:
Ondokuz Mayıs University
Conditions:
Chronic Rhinosinusitis
Children
Eligibility:
All Genders
6-17 years
Phase:
PHASE4
Brief Summary
The place of systemic corticosteroids in the treatment of children with chronic rhinosinusitis (CRS) remains unclear. We aimed to assess the effectiveness and tolerability of oral methylprednisolone (...
Eligibility Criteria
Inclusion
- All patients presented with nasal and/or postnasal purulence, and one or more of the following symptoms: nasal obstruction, cough, halitosis, headache, or facial pain/pressure. The diagnosis of CRS was made on the basis of sinonasal symptoms and signs present for a period of more than 3 months in the presence of abnormalities on coronal sinus CT scans.
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Exclusion
- Patients were excluded if they had used systemic corticosteroids in the last 2 months prior to the study, systemic antibiotics and inhaler or intranasal corticosteroids in the last 4 weeks prior to the study or if they had other respiratory disorders (cystic fibrosis, ciliary dyskinesia, nasal polyps, large adenoids, asthma), immune deficiency, systemic disease, gastro-esophageal reflux, aspirin sensitivity, and acquired or congenital sinonasal abnormalities, or a contraindication to corticosteroid use.
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Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT01205984
Start Date
July 1 2007
End Date
April 1 2010
Last Update
September 21 2010
Active Locations (1)
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1
Gazi University Faculty of Medicine
Ankara, Turkey (Türkiye), 06500