Status:
UNKNOWN
Effect of Pioglitazone on Testosterone in Eugonadal Men With Type 2 Diabetes Mellitus - A Pilot Study
Lead Sponsor:
Post Graduate Institute of Medical Education and Research, Chandigarh
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
MALE
25-50 years
Brief Summary
To study the effects of pioglitazone on the steroidogenic enzyme axis in eugonadal men with type 2 diabetes mellitus.
Detailed Description
Several clinical studies demonstrated that pioglitazone not only improves insulin sensitivity but also decreases plasma androgen concentrations (DHEAS and androstenedione) in women with polycystic ova...
Eligibility Criteria
Inclusion
- HbA1c level of 7.5% or less on stable dosages of sulphonylurea (glimepiride 1-6mg/day) and metformin (1-2g/day) for at least six weeks and BMI of 20-30 kg/m2.
Exclusion
- hepatic impairment, coronary artery disease and or heart failure, renal failure, those who requires insulin therapy or HbA1c \>7.5%, presence of macular edema and serum albumin \<3gm/dL.
Key Trial Info
Start Date :
September 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2012
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT01206400
Start Date
September 1 2010
End Date
January 1 2012
Last Update
June 30 2011
Active Locations (1)
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1
PGIMER
Chandigarh, Chandigarh, India, 160012