Status:
COMPLETED
Prognostic Factors of Acute Splenic Sequestration
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
URC-CIC Paris Descartes Necker Cochin
Conditions:
Anemia; Drepanocytic
Eligibility:
All Genders
3-6 years
Phase:
NA
Brief Summary
Acute splenic sequestration is a frequent and life threatening complication occurring in approximately 10 % of homozygous children. Maximal incidence is between 6 and 18 months. The investigators for...
Detailed Description
A prospective multicentric analysis will be conducted in a cohort of 150 SS or S ß ° children diagnosed at birth, included at 3 -5 months and followed up to the age of 24 months. Five visits, superim...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- Children aged 3 to 6 months
- homozygous (SS) or S beta° sickle cell disease diagnosed by neonatal screening
- With no history of acute splenic sequestration
- Signed parental consent
- Patient covered by national insurance scheme or CMU
- Exclusion criteria :
- Children with other SCD genotype
- Children with congenital anatomical asplenia
- Children with previous episode of acute splenic sequestration
- Absence of possible follow-up
- Simultaneous enrolment in another biomedical research
Exclusion
Key Trial Info
Start Date :
August 12 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 7 2017
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT01207037
Start Date
August 12 2010
End Date
November 7 2017
Last Update
September 8 2025
Active Locations (1)
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1
Necker Hospital
Paris, France, 75015