Status:
ACTIVE_NOT_RECRUITING
Phase 1 Follow-on Study of AAV2-hRPE65v2 Vector in Subjects With Leber Congenital Amaurosis (LCA) 2
Lead Sponsor:
Spark Therapeutics, Inc.
Conditions:
Leber Congenital Amaurosis
Eligibility:
All Genders
8+ years
Phase:
PHASE1
PHASE2
Brief Summary
The study is a follow-on to a Phase 1 dose-escalation and safety study.
Detailed Description
The study is a follow-on to a Phase 1 dose-escalation and safety study (closed to enrollment as of June 2009). Up to twelve adults and children with a molecular diagnosis of biallelic RPE65 mutations,...
Eligibility Criteria
Inclusion
- Prior participation in Phase 1 study with unilateral, subretinal administration of AAV2-hRPE65v2.
- Visual acuity equal to or greater than light perception.
- Sufficient viable retinal cells in contralateral, previously uninjected eye, as determined by non-invasive means, such as optical coherence tomography (OCT) and/or ophthalmoscopy. Must have either: 1) an area of retina within the posterior pole of \> 100 µm shown on OCT; 2) ≥ 3 disc areas of retina without atrophy or pigmentary degeneration within the posterior pole; or 3) remaining visual field within 50 degrees of fixation.
- Willingness to adhere to protocol and long-term follow-up as evidenced by written informed consent or parental permission and subject assent (where applicable).
Exclusion
- Unable or unwilling to meet requirements of the study.
- Participation in any other study of an investigational drug within the past six months.
- Use of retinoid compounds or precursors that could potentially interact with the biochemical activity of the RPE65 enzyme; individuals who discontinue use of these compounds for 18 months may become eligible.
- Prior intraocular surgery within six months.
- Known sensitivity to medications planned for use in the peri-operative period.
- Pre-existing eye conditions, such as glaucoma, or complicating systemic diseases that would preclude the planned surgery or could interfere with the interpretation of study. Complicating systemic diseases would include those in which the disease itself, or the treatment for the disease, can alter ocular function. Examples are malignancies whose treatment could affect central nervous system function (for example: radiation treatment of the orbit; leukemia with CNS/optic nerve involvement). Subjects with diabetes or sickle cell disease would be excluded if they had any manifestation of advanced retinopathy (e.g. macular edema or proliferative changes). Also excluded would be subjects with immunodeficiency (acquired or congenital) as there could be susceptibility to opportunistic infection (such as CMV retinitis).
- Individuals of childbearing potential who are pregnant or unwilling to use effective contraception for four months following vector administration.
- Any other condition that would not allow the potential subject to complete follow-up examinations during the course of the study and, in the opinion of the investigator, makes the potential subject unsuitable for the study.
- Subjects will NOT be excluded based on their gender, race, or ethnicity.
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01208389
Start Date
November 1 2010
End Date
October 1 2027
Last Update
April 29 2025
Active Locations (1)
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1
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104