Status:
COMPLETED
Auto-immunity and Pulmonary Arterial Hypertension
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
URC-CIC Paris Descartes Necker Cochin
Conditions:
Pulmonary Arterial Hypertension
HIV Infection
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The investigators have recently evidenced the presence of antibodies to endothelial cells and fibroblasts in patients with idiopathic or SSc-associated PAH. The investigators also have identified seve...
Detailed Description
Two hundred and fifty patients with PAH will be included: 65 patients with idiopathic PAH (iPAH), 20 with PAH associated with HIV infection, 20 with porto-pulmonary hypertension, 20 with PAH secondary...
Eligibility Criteria
Inclusion
- age over 18
- for PAH patients: pre-capillary PAH evidenced by right-heart catheterization
- no associated systemic disease for idiopathic PAH patients
- for HIV patients, HIV1 infection confirmed by ELISA and western blot
- for patients with porto pulmonary hypertension: evidence by endoscopy of esophageal varices, confirmation of hepatic venous pressure gradient over 5 mmHg by catheterization of the hepatic veins
- for patients with congenital heart defect: evidence by imaging of atrial or ventricular septal defect, or patent ductus arterious and confirmed by heart catheterization
- patients with SSc will fulfill the American College of Rheumatology (ACR) and the LEROY and MEDSGER criteria
- patients with MCTD will fulfill the criteria for MCTD
- patients with SLE will fulfill the updated and revised ACR criteria
- patients with Sjögren's syndrome will fulfill the American-European consensus group criteria
- patients with chronic thromboembolic pulmonary hypertension: Lung scintiscan showing segmental mismatched perfusion defects and confirmation by angiography of the occlusion and the chance of success of endarterectomy according to the location of disease
- Signed written informed consent
- Patients with health insurance
Exclusion
- age under 18
- pregnant women
- absence of written informed consent
- associated malignant tumor
Key Trial Info
Start Date :
June 15 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 15 2017
Estimated Enrollment :
629 Patients enrolled
Trial Details
Trial ID
NCT01208792
Start Date
June 15 2010
End Date
May 15 2017
Last Update
September 12 2025
Active Locations (3)
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1
Pneumology Department, Antoine Béclère Hospital
Clamart, France, 92000
2
Internal Medicine Department, Claude Huriez Hospital
Lille, France, 59000
3
Internal Medicine Department, Cochin Hospital
Paris, France, 75014