Status:
COMPLETED
Effect of Whole Body Periodic Acceleration on Airway Endothelial Function
Lead Sponsor:
University of Miami
Conditions:
Healthy
Smokers
Eligibility:
All Genders
20-65 years
Phase:
NA
Brief Summary
In the present proposal the investigators wish to assess the effect of a single session with the device known as Exer-Rest® which applies Whole Body Periodic Acceleration (WBPA) on baseline airway blo...
Detailed Description
Endothelial shear stress activates nitric oxide synthase (NOS), leading to endothelium-dependent vasodilation. This can be accomplished through exercise or with a device known as Exer-Rest® which appl...
Eligibility Criteria
Inclusion
- 15 healthy never-smokers, 15 smokers (\> than 1 year smoke history) and 15 never-smokers asthmatics; FEV1 \> 80% (except for asthmatics subjets)
Exclusion
- Women of childbearing potential who do not accepted birth control measures; pregnant and breast feeding; cardiovascular disease or use of cardiovascular drugs; respiratory infection during the 4 weeks preceding the study; use of inhaled or systemic glucocorticoids, leukotriene modifiers or theophyllines in asthmatics; FEV1 \< 80% on the screening day (excepted for asthmatics subjets)
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT01213706
Start Date
October 1 2009
End Date
May 1 2011
Last Update
August 10 2016
Active Locations (1)
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1
Pulmonary Human Research Laboratory, University of Miami Miller School of Medicine
Miami, Florida, United States, 33136