Status:
COMPLETED
Study of Inhaled Carbon Monoxide to Treat Idiopathic Pulmonary Fibrosis
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
University of California, San Francisco
Conditions:
Idiopathic Pulmonary Fibrosis
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether low concentration inhaled carbon monoxide is effective in treating idiopathic pulmonary fibrosis.
Detailed Description
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by destruction of normal epithelial structure, proliferation of fibroblasts, and deposition of connective-tissue matri...
Eligibility Criteria
Inclusion
- Adults above the age of 18 and equal to or below the age of 85
- Diagnosis of IPF by biopsy or
- American Thoracic Society (ATS)/European Respiratory Society (ERS)/ Latin American Thoracic Association (ALAT) Guidelines (Am J Respir Crit Care Med Vol 183. pp 788-824,2011)
- Forced vital capacity (FVC) greater than or equal to 50% predicted, greater than or equal to one month off all medications prescribed for IPF
Exclusion
- Evidence of active infection within the last month
- Significant obstructive respiratory defect
- Supplemental oxygen required to maintain an oxygen saturation over 88% at rest
- History of myocardial infarction within the last year, heart failure within the last 3 years or cardiac arrhythmia requiring drug therapy
- History of smoking within 4 weeks of screening
- Pregnancy or lactation
- Participation in another therapeutic clinical trial
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT01214187
Start Date
July 1 2011
End Date
April 1 2015
Last Update
June 14 2017
Active Locations (8)
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1
University of California San Francisco
San Francisco, California, United States, 94143
2
University of Illinois Chicago
Chicago, Illinois, United States, 60612
3
University of Chicago
Chicago, Illinois, United States, 60637
4
Tulane University
New Orleans, Louisiana, United States, 70112