Status:
TERMINATED
Study of the Inhibition of [11C]R-rolipram Binding to Brain Phosphodiesterase - 4 (PDE-4) by HT-0712
Lead Sponsor:
Dart NeuroScience, LLC
Conditions:
Healthy Elderly Volunteers
Eligibility:
All Genders
55-80 years
Phase:
PHASE1
Brief Summary
This Positron Emission Tomography (PET) imaging study is designed to explore the relationship between HT-0712 dose level and inhibition of brain phosphodiesterase-4 activity, in order to optimize the ...
Detailed Description
The objective of this project is to demonstrate the inhibition of human brain PDE4 by HT-0712, by measuring the inhibition of \[11C\]R-rolipram binding, a radiotracer which also binds to and inhibits ...
Eligibility Criteria
Inclusion
- Main
- Healthy, elderly, non-smoking men and post-menopausal women
- Ability to give informed consent
- Main
Exclusion
- Current or history of uncontrolled hypertension, major depression, Parkinson's disease, stroke and diabetes.
- Physical or behavioral conditions that may alter brain function
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT01215552
Start Date
September 1 2010
End Date
January 1 2011
Last Update
June 1 2011
Active Locations (1)
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1
Brookhaven National Laboratory
Upton, New York, United States, 11973