Status:
COMPLETED
Impact of Combination of Clopidogrel With Aspirin on Postoperative Bleeding in Coronary Surgical Patients
Lead Sponsor:
Groupe Hospitalier Pitie-Salpetriere
Conditions:
Coronary Surgery
Hemorrhage
Eligibility:
All Genders
18+ years
Brief Summary
Aims Aspirin combined with clopidogrel is the treatment of choice for acute coronary syndromes. Although the maintenance of aspirin until surgery does not affect postoperative bleeding after coronary ...
Detailed Description
Impact of combination of clopidogrel with aspirin on postoperative bleeding and platelets functions in coronary surgical patients treated prophylactically with tranexamic acid. Introduction Major car...
Eligibility Criteria
Inclusion
- all patients undergoing isolated first-time coronary artery by-pass grafting will be enrolled.
Exclusion
- patient who do not want to be include
- pregnant
- patient \< 18 yrs old
- emergency procedure with failed percutaneous transluminal coronary angioplasty
- off-pump coronary surgery
- patients in whom a mechanical support (ECMO) or intra-aortic balloon pump will be required for a difficult weaning from cardiopulmonary bypass
- patients who will not have received any oral antiplatelet agents within 5 days prior surgery
- patient who will be preoperatively exposed to platelet glycoprotein IIb/IIIa inhibitors
- Patients treated with aspirin and clopidogrel and in whom clopidogrel will be stopped more than 5 days before surgery
Key Trial Info
Start Date :
December 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2010
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01216150
Start Date
December 1 2009
End Date
October 1 2010
Last Update
June 23 2011
Active Locations (1)
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1
Hopital Pitié Salpêtrière
Paris, France, 75013