Status:
TERMINATED
Effects of Intravenous (IV) Citalopram on Emotional Brain Activity in Healthy Young and Elderly Adults
Lead Sponsor:
Rotman Research Institute at Baycrest
Collaborating Sponsors:
Centre for Addiction and Mental Health
University of Toronto
Conditions:
Healthy Young and Elderly Volunteers
Eligibility:
MALE
20+ years
Phase:
NA
Brief Summary
Antidepressant medications known as selective serotonin reuptake inhibitors (SSRIs) are most commonly prescribed to treat depression and anxiety. How antidepressants work on the brain to alter mood an...
Eligibility Criteria
Inclusion
- Male aged 60 or older (elderly group)
- Male aged 20-40 (younger adult group)
- English speaking
- Right-handed
- Non-smoker
- Score of 27 or greater on the Mini Mental State Exam
Exclusion
- Unstable medical, cardiac, or neurological illness (including stroke, brain tumour, epilepsy, significant head injury, Alzheimer's, Parkinson's or Huntington's disease)
- Laboratory results indicating unanticipated illness or intolerability of blood drawing procedures or of study drug
- Current or lifetime Axis-I psychiatric diagnosis on the DSM-IV/SCID (i.e., Module A: Mood, Module F: Anxiety, Module B \& C: Psychosis)
- History of drug or alcohol abuse within one year, or lifetime history of alcohol or drug dependence (i.e., SCID Module E: Substance Abuse, or clinically significant urine toxicology screen)
- History of non-tolerance to SSRI therapy; including history of SSRI-related syndrome of inappropriate antidiuretic hormone secretion (SIADH) or sinus bradycardia on ECG (less than 50 beats per minute)
- Contraindication to MRI (as per MRI Contraindication Screening Form)
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT01216449
Start Date
April 1 2009
End Date
March 1 2016
Last Update
March 11 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Rotman Research Institute at Baycrest
Toronto, Ontario, Canada, M6A2E1