Status:
COMPLETED
The Effect of Non-surgical Periodontal Treatment in the Renal Function of Patients With Chronic Kidney Disease: RCT
Lead Sponsor:
University of Athens
Conditions:
Chronic Kidney Disease
Periodontitis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Periodontal disease is a bacterially-induced inflammation. As such, it can become a point of entry of bacteria, toxins and cytokines into the systemic blood circulation, thus adversely affecting the f...
Eligibility Criteria
Inclusion
- Chronic Kidney Disease (Stage II, III, IV)
- At least 12 teeth present in the oral cavity
- Moderate to severe chronic periodontitis, which is defined as: at least 8 surfaces with periodontal pocket depth (PPD) ≥5mm and at least 4 surfaces with Clinical Attachment Loss (CAL) ≥4mm, distributed in at least two quadrants.
Exclusion
- Patients that have had a renal transplant or undergoing dialysis
- Acute infections or use of antibiotics in the past 3 months.
- Auto-immune diseases, conditions that cause immunosuppression or use of immunosuppressant medication.
- Systemic conditions that require antibiotic prophylaxis for routine periodontal therapy.
- Non-surgical periodontal therapy in the past 6 months or surgical periodontal therapy in the past 12 months.
- Use of medication that can cause gingival hyperplasia such as cyclosporine or fenintoin.
- Myocardial infarction or cerebral vascular incident in the past 12 months or uncontrolled angina.
Key Trial Info
Start Date :
January 30 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 18 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01217281
Start Date
January 30 2012
End Date
June 18 2022
Last Update
July 24 2025
Active Locations (1)
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1
University of Athens, Dental School, Department of Periodontology
Athens, Greece, 11527