Status:
COMPLETED
Metformin to Reduce Heart Failure After Myocardial Infarction
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
ST Elevation Myocardial Infarction (STEMI)
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The investigators will evaluate the effect of metformin therapy during 4 months in non-diabetic patients following ST-elevation myocardial infarction on left ventricular ejection fraction as measured ...
Detailed Description
In this trial, the investigators will evaluate the effect of metformin therapy following ST-elevation myocardial infarction (STEMI) in a total of 380 non-diabetic patients. This trial is a randomized,...
Eligibility Criteria
Inclusion
- The diagnosis acute MI defined by chest pain suggestive for myocardial ischemia for at least 30 minutes, the time from onset of the symptoms less than 12 hours before hospital admission, and an ECG recording with ST- segment elevation of more than 0.1 mV in 2 or more leads.
- Successful primary PCI (post-procedural TIMI 2/3);
- At least one stent sized ≥ 3.0 mm;
- Eligible for 3T CMR imaging;
- Verbal followed by written informed consent.
Exclusion
- rescue PCI after thrombolytic therapy;
- need for emergency coronary artery bypass grafting;
- creatinin \>177 μmol/L measured pre-PCI;
- Younger than 18 years;
- Mechanical ventilation;
- Diabetes;
- Prior myocardial infarction;
- Contra-indication to metformin (see safety);
- The existence of a life-threatening disease with a life-expectancy of less than 6 months.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2015
Estimated Enrollment :
380 Patients enrolled
Trial Details
Trial ID
NCT01217307
Start Date
January 1 2011
End Date
October 1 2015
Last Update
January 30 2018
Active Locations (1)
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1
University Medical Center Groningen
Groningen, Netherlands, 9700RB