Status:
COMPLETED
Nephrolithiasis Prevention by Lemon Juice
Lead Sponsor:
Mario Negri Institute for Pharmacological Research
Conditions:
Nephrolithiasis
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
Calcium oxalate nephrolithiasis is a relatively common disease. The prevalence in the general population may range from 10 to 12 percent, and 0.4 to 1 percent of new cases are reported every year acco...
Detailed Description
BACKGROUND Calcium oxalate nephrolithiasis is a relatively common disease. The prevalence in the general population may range from 10 to 12 percent, and 0.4 to 1 percent of new cases are reported ever...
Eligibility Criteria
Inclusion
- male and female \>18 years
- history of recurrent nephrolithiasis, with one o more calcium oxalate or mixed (calcium oxalate and phosphate, calcium oxalate and uric acid) stone formation over the last 5 years
- at least one kidney stone at baseline documented by renal echography and/or X-ray evaluation.
- written informed consent
Exclusion
- Obstructive uropathy, chronic urosepsis, renal failure (serum creatinine \>1.8 mg/dl), renal tubular acidosis, primary hyperparathyroidism, primary hyperoxaluria, pure uric acid and cystine stones, medullary sponge kidney
- lithotripsy treatment within the last 6 months
- active peptic ulcer disease, gastric esophagus reflux
- concomitant clinical conditions that might affect completion of the study or jeopardize data interpretation
- pharmacological therapy for stone disease over the last month
- impossibility to assess the number of kidney stones
- inability to provide an informed consent
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 16 2021
Estimated Enrollment :
203 Patients enrolled
Trial Details
Trial ID
NCT01217372
Start Date
January 1 2009
End Date
February 16 2021
Last Update
April 1 2021
Active Locations (1)
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1
Unit of Nephrology and Dialysis
Bergamo, Italy, 24128