Status:
COMPLETED
The Effect of Anti-epileptic Drugs on Mitochondrial Activity
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Epilepsy
Eligibility:
All Genders
3-18 years
Brief Summary
This study is based on the hypothesis that antiepileptic drugs (other than Valproic acid) have an effect on the mitochondrial oxidative phosphorylation. The objective of this study is to evaluate thi...
Detailed Description
Antiepileptic drugs adverse reactions, including hepatotoxicity, are rare but potentially fatal, especially among children. Although the mechanism of the liver toxicity remains elusive, mitochondrial ...
Eligibility Criteria
Inclusion
- Children between the ages of 3 and 18 years old, who suffer from new onset epilepsy as diagnosed by a certified pediatric neurologist, who do not suffer from a ''metabolic'' disorder, are treated by a single antiepileptic drug, and are not receiving any other type of medication on a chronic basis were included
Exclusion
- Children younger than 3 years of age or older than 18 years of age, children who were suspected or known to suffer from a ''metabolic'' disorder or liver dysfunction, children who were under treatment, by any medication on a chronic basis, at the time of the study were excluded.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01218321
Start Date
January 1 2011
End Date
June 1 2012
Last Update
March 6 2018
Active Locations (1)
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1
Hadassah-Hebrew University Medical Center
Jerusalem, Israel, 91240