Status:
COMPLETED
The Use of Fractional Exhaled Nitric Oxide in the Identification of Non-adherence in Difficult Asthma
Lead Sponsor:
Liam Heaney
Collaborating Sponsors:
Queen's University, Belfast
Asthma UK
Conditions:
Asthma
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Asthma usually responds to standard doses of inhaled steroids with or without additional therapies to control their symptoms. However, approximately 5-10% do not respond to this treatment strategy and...
Detailed Description
Hypothesis: In a difficult asthma population, a significant reduction in fractional exhaled nitric oxide (FeNO) or sputum eosinophils after a directly observed inhaled steroid challenge will distingu...
Eligibility Criteria
Inclusion
- Phase 1
- Subjects with difficult to control asthma
- FeNO \> 45 ppb at a flow rate of 50 ml/sec on 2 sequential occasions at clinical review
- Non-adherent group: \< 50% prescription filling of inhaled corticosteroid therapy in the previous 6 months
- Adherent group: \> 75% prescription filling of inhaled corticosteroid therapy in the previous 6 months
- Phase 1
Exclusion
- Current smoker
- Pregnancy
- Other significant respiratory disease
- Phase 2 Inclusion Criteria:
- Subjects with difficult to control asthma
- FeNO \> 45 ppb at a flow rate of 50 ml/sec on 2 sequential occasions at clinical review
- Phase 2
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01219036
Start Date
October 1 2008
End Date
July 1 2011
Last Update
February 3 2012
Active Locations (1)
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1
Regional Respiratory Centre, Belfast City Hospital
Belfast, United Kingdom, BT9 7AB