Status:
COMPLETED
Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET
Lead Sponsor:
Cairo University
Collaborating Sponsors:
Ahmed Elgazzar Hospital
Conditions:
Infertility
Eligibility:
FEMALE
30-42 years
Phase:
PHASE2
Brief Summary
The aim of this randomized controlled trial is to compare the efficacy of extended high dose letrozole regimen (5 mg /day for the first 5 days of cycle and 2.5 mg/day for the subsequent 3 days ) with ...
Detailed Description
Poor response to controlled ovarian stimulation (COH) is estimated to occur in 9-24 % of all IVF cycles. Although there is no consensus on the definition of poor response to COH, inability to produce ...
Eligibility Criteria
Inclusion
- Patients who produced less than three mature follicles in response to standard GnRH agonist long protocol in their first IVF cycle
Exclusion
- Age \> 42 years
- FSH\> 12 IU/L
- Irregular menstrual cycles
- Unilateral ovary
- Polycystic ovary syndrome
- Endometriosis
- Male factor of infertility requiring ICSI
- History of recurrent miscarriage
- Endocrinologic disorders
- Systemic disease contraindicating pregnancy
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
136 Patients enrolled
Trial Details
Trial ID
NCT01219153
Start Date
September 1 2008
End Date
December 1 2010
Last Update
July 12 2011
Active Locations (1)
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1
Ahmed Elgazzar hospital , Assisted conception unit
Giza, Egypt