Status:
COMPLETED
Validation of the Accuracy of DNA Fingerprinting Using Polar Bodies and Embryonic Cells
Lead Sponsor:
Reproductive Medicine Associates of New Jersey
Conditions:
DNA Fingerprinting
Eligibility:
FEMALE
21-43 years
Phase:
NA
Brief Summary
The purpose of this study is to validate the ability to assess the genetic differences (DNA fingerprinting) on polar bodies (excess genetic material given off from the egg) and cells so that this tech...
Detailed Description
Our group has recently validated a technique involving whole genomic amplification followed by single nucleotide polymorphisms (SNP) analysis which allows DNA fingerprinting of single cells. Given tha...
Eligibility Criteria
Inclusion
- Major Inclusion: The following are major inclusion criteria:
- Maximum of one prior failed IVF treatment cycle
- Female partner less than 43 years of age
- Normal day 3 FSH level (\<12 mIU/mL)
- Basal antral follicle count greater than or equal to 8
- Ejaculated sperm specimen from the male partner with greater than 100,000 total motile
- Donor sperm okay if patient is willing to purchase 3 extra vials for DNA testing
- Exclusions: The following are exclusion criteria:
- Diagnosis of chronic anovulation secondary to polycystic ovarian disease
- Diagnosis of endometrial insufficiency
- Clinical indication for PGD
- Testicular biopsy or aspiration procedures to obtain sperm
Exclusion
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01219517
Start Date
January 1 2008
End Date
December 1 2009
Last Update
January 23 2013
Active Locations (6)
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1
Colorado Center for Reproductive Medicine
Lone Tree, Colorado, United States, 80124
2
Reproductive Medicine Associates of Connecticut
Norwalk, Connecticut, United States, 06850
3
Reproductive Medicine Associates of Michigan
Troy, Michigan, United States, 48084
4
Reproductive Medicine Associates
Morristown, New Jersey, United States, 07960