Status:
TERMINATED
EScitalopram PIndolol ONset of Action
Lead Sponsor:
Markus KOSEL
Collaborating Sponsors:
University Hospital, Geneva
University of Lausanne Hospitals
Conditions:
Unipolar Depression
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
The main purpose of this study is to determine whether the antidepressant response of escitalopram 30mg/day or escitalopram 20mg/day + pindolol, a beta blocker, is different (faster) compared to a sta...
Detailed Description
Antidepressant drug therapy is the primary therapeutic treatment option in moderate to severe Major Depressive Disorder. However, clinically significant antidepressant response needs sustained treatme...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- patients aged between 18 and 65 years old
- patients suffering from major depression according to DSM-IV with a MADRS score of at least 25 and not treated by an antidepressant at the time of inclusion with the exception of non-responders to antidepressant for a period of at least 6 weeks or not tolerating an ongoing antidepressant necessitating a change of the antidepressant(excluding fluoxetine and irreversible MAOI)
- informed consent
- Exclusion criteria:
- any other Axis I disorder excluding anxiety disorder not dominating the clinical picture, nicotine abuse
- non-responders to escitalopram in the past
- already taking pindolol
- pregnancy and breast feeding
- contraindication to one of the two treatments (medical conditions, drug treatments)
- significant somatic comorbidity interfering with the study procedures
- high risk of suicidality
- women of childbearing age not having a safe means of contraception
Exclusion
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01219686
Start Date
October 1 2010
End Date
June 1 2013
Last Update
May 27 2015
Active Locations (1)
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1
Centre de Thérapies Breves (CTB), Secteur Jonction
Geneva, Switzerland, 1205