Status:
COMPLETED
Polarization Sensitive Retinal Tomography for Glaucoma Diagnosis
Lead Sponsor:
Courtney Frazier Swaney
Collaborating Sponsors:
National Eye Institute (NEI)
Conditions:
Glaucoma
Eligibility:
All Genders
40-80 years
Brief Summary
The proposed human clinical studies have three main objectives: 1. To determine reproducibility of peripapillary birefringence maps and identify features that measure the health of the RNFL. 2. To de...
Detailed Description
This study evaluates RNFL Birefringence in normal and glaucoma human subjects: The primate experimental glaucoma study will characterize the spatial and temporal dynamics of RNFL birefringence during ...
Eligibility Criteria
Inclusion
- patient age between 40 and 80, visual acuity score of 20/40 or better; spherical refraction within ± 5 diopters, cylinder refraction within ± 3 diopters, ability to cooperate with study procedures and personnel and to perform tests reliably. Case-control assignment for the human clinical trials is based on medical and ocular history and on a comprehensive eye examination (including intraocular pressure history, standard disc photography and Humphrey-Zeiss 24-2 visual field test) by a glaucoma specialist.
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Exclusion
- discernable anomaly of the anterior chamber, uveitis, significant opacification of the cornea or crystalline lens, eyes with secondary glaucoma, eyes with pigmentary or pseudoexfoliation glaucoma, concurrent active eye disease in the study eye that may affect intraocular pressure or its measurement, patients on kidney dialysis, eyes with proliferative or severe nonproliferative retinopathy, retinal detachment, retinitis pigmentosa, or other significant retinopathy, eyes with field loss attributed to a non-glaucoma condition, dilated pupil diameter less than 4mm, and visual fields \< 20 degrees.
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Key Trial Info
Start Date :
August 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT01222065
Start Date
August 1 2007
End Date
March 1 2011
Last Update
March 27 2012
Active Locations (1)
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1
Eye Institute of Austin
Austin, Texas, United States, 78757