Status:
COMPLETED
Impact of Vitamin D Therapies on Chronic Kidney Disease
Lead Sponsor:
University of Kansas Medical Center
Conditions:
Chronic Kidney Disease (CKD)
End-stage Renal Disease (ESRD)
Eligibility:
All Genders
21-90 years
Phase:
NA
Brief Summary
This investigation will consist of a prospective study utilizing two separate populations of patients with 25(OH)D deficiency, one population with chronic kidney disease (CKD) and one with normal rena...
Detailed Description
Vitamin D helps form and strengthens bones by allowing the body to absorb calcium. Vitamin D helps the immune system fight infection as well as helps keep muscles strong. Without enough vitamin D, bon...
Eligibility Criteria
Inclusion
- Chronic kidney disease w/GFR\<35ml/min
- Nutritional vitamin D deficiency, defined as 25(OH)D \< 25ng/ml
- Secondary hyperparathyroidism, PTH\>75pg/mL
Exclusion
- Active infection
- Recent hospitalization for acute illness (within last month)
- Refusal to study participation
- History of chronic inflammatory disease process (i.e. inflammatory bowel, rheumatoid arthritis, SLE, etc.)
- Allergy to cholecalciferol or calcitriol
- History of parathyroidectomy
- Functional renal transplant within 5 years
- Current treatment with immunosuppressant medications
- Noncompliance with prescribed medications
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT01222234
Start Date
October 1 2010
End Date
August 1 2012
Last Update
May 16 2016
Active Locations (1)
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1
University Of Kansas Medical Center
Kansas City, Kansas, United States, 66160