Status:
COMPLETED
Nicotinic Modulation of the Default Network
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Magnetic Resonance Imaging
Cognition
Eligibility:
All Genders
21-50 years
Phase:
NA
Brief Summary
Many disorders where attentional problems are a hallmark, such as Alzheimer's disease and schizophrenia, display abnormal regulation of the so-called default network of resting brain function that mai...
Detailed Description
This study only enrolls healthy non-smokers. Participants perform attention tasks while undergoing functional Magnetic Resonance Imaging on three separate days. Across the three days, three difference...
Eligibility Criteria
Inclusion
- Age 21 through 50.
- Did not consume cigarettes, cigarillos, cigars, or other tobacco or nicotine-containing products more than 20 times in lifetime, and did not use any nicotine-containing product at all within the last two years.
- Normal or corrected to normal vision (at least 20/80).
Exclusion
- Presence of metal objects in the body, implanted electronic devices, or any other counter indication for MRI.
- Claustrophobia.
- Major psychiatric disorders including mood, anxiety or psychotic disorders.
- Cardiovascular or cerebrovascular disease, such as history of myocardial infarction, heart failure, angina, stroke, severe arrhythmias, or EKG abnormalities.
- Kidney or liver disease.
- Hypertension (resting systolic BP above 140 or diastolic above 85 mm Hg).
- Hypotension (resting systolic BP below 95 or diastolic below 60).
- Use of any prescription or over-the-counter drug other than supplements and birth control.
- History of or current neurological illnesses, such as stroke, seizures, dementia or organic brain syndrome.
- Learning disability, attention deficit disorder, or any other condition that impedes memory and attention.
- Glaucoma, organic pyloric stenosis, uremia or renal insufficiency.
- Prostatic hypertrophy, bladder neck obstruction or urethral stricture.
- Left-handed or ambidextrous.
- Pregnant as determined by urine test, or breast-feeding.
- History or current diagnosis of drug or alcohol abuse or dependence.
- IQ \< 85 as estimated by the WASI vocabulary subtest.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01223404
Start Date
October 1 2010
End Date
September 1 2013
Last Update
August 19 2019
Active Locations (2)
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1
National Institute on Drug Abuse, Intramural Research Program
Baltimore, Maryland, United States, 21224
2
Maryland Psychiatric Research Center
Baltimore, Maryland, United States, 21228