Status:
COMPLETED
Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Endothelial Function
Lead Sponsor:
Odense University Hospital
Conditions:
Endothelial Dysfunction
Atherosclerosis
Eligibility:
All Genders
18-81 years
Phase:
PHASE4
Brief Summary
The aim of this study was to measure the effect of moderate and intensive lipid-lowering treatment with rosuvastatin on the endothelial function.
Eligibility Criteria
Inclusion
- STEMI
- no prior treatment with statins
Exclusion
- age below 18 or above 81 years
- unconscious patients
- serum creatinine \> 176μmol/L
- total-cholesterol \> 7.0 mmol/l
- hypothyreoidism ((TSH \> 1.5 x ULN (upper limit of normal))
- current liver disease (ALAT \> 2 x ULN)
- unexplained creatine kinase \> 3 x ULN
- alcohol or drug abuse within the last five years
- prior myopathy or serious hypersensitivity reaction caused by statins
- women with childbearing potential who were not using chemical or mechanical contraception
- pregnant or breastfeeding women
- history of malignancy unless a disease-free period of more than five years was present
- patients with abnormal lung function test (LFT)
- participation in another investigational drug study less than four weeks before enrolment in the present study
- treatment with cyclosporine or fibrates.
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
87 Patients enrolled
Trial Details
Trial ID
NCT01223625
Start Date
November 1 2007
End Date
June 1 2010
Last Update
October 19 2010
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Cardiology, Odense University Hospital
Odense, Fuenen, Denmark, 5000