Status:
RECRUITING
Age and Insulin Resistance
Lead Sponsor:
University of Lausanne
Collaborating Sponsors:
Centre Hospitalier Universitaire Vaudois
Conditions:
Obesity
Physical Inactivity
Eligibility:
All Genders
60-80 years
Phase:
NA
Brief Summary
Insulin resistance is a crucial factor for the development of type 2 diabetes and a major health problem for older adults. It is the principal mechanism by which obesity is considered to increase the ...
Eligibility Criteria
Inclusion
- Age 60-80
- Sedentary or highly trained
- BMI 18-40
- Non-Smoker
- Normal glucose tolerance or impaired glucose tolerance
- Willingness to comply with the protocol
Exclusion
- Contraindication to moderate exercise or clinical conditions precluding from joining an exercise program, such as clinically significant cardiovascular disease, peripheral vascular disease, uncontrolled hypertension, neurological or orthopedic disease
- Recent weight loss or weight gain
- Known diabetes
- Known drugs to affect glucose homeostasis such as nicotinic acid, glucocorticoids
- Severe anemia or lipid disturbances, hepatic or renal disease
- Recent history of cancer
- Hypothyroidism
- Recent hormone replacement therapy
- Known allergy to lidocaine or other local anesthetic
- Positive stress test
- Active alcohol or substance abuse
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01224886
Start Date
October 1 2010
End Date
December 1 2028
Last Update
December 5 2024
Active Locations (2)
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1
University of Bern
Bern, Switzerland
2
UNIL and CHUV
Lausanne, Switzerland, 1005