Status:
COMPLETED
Impact of Vitamin A Supplementation on Immune System in Multiple Sclerosis Patients
Lead Sponsor:
Tehran University of Medical Sciences
Conditions:
Relapsing Remitting Multiple Sclerosis
Eligibility:
All Genders
20-45 years
Phase:
PHASE4
Brief Summary
The aim of this study is to study the comparison between the effects of supplementation with 25000 IU preformed vitamin A (retinyl palmitate) or placebo for 6 months on immune system and Th1/Th2 balan...
Detailed Description
Multiple Sclerosis (MS) is a chronic inflammatory disease where Th1 like responses from myelin-specific CD4+ T cells, as secretion of pro-inflammatory IFN-g, are believed to play a major role in the p...
Eligibility Criteria
Inclusion
- Patients who have used interferon beta in last 3 months. Patients with 1-5 EDSS
Exclusion
- Patients who have diseases which affect on Th1/Th2 balance such as asthma, active viral infections, and autoimmune diseases, OR
- Patients who have allergy to vitamin A compounds, OR
- Patients who have used vitamin supplements in last 3 months.
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2014
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01225289
Start Date
October 1 2009
End Date
January 1 2014
Last Update
March 14 2014
Active Locations (2)
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1
Tehran University of Medical Sciences, School of Public Health Tehran, Tehran, Iran, Islamic Republic o
Tehran, Tehran Province, Iran
2
Tehran University of Medical Sciences, School of Public Health
Tehran, Tehran Province, Iran