Status:
COMPLETED
Study of Sodium Bicarbonate in Kidney Transplant Recipients
Lead Sponsor:
University of Utah
Conditions:
Kidney Transplantation
Eligibility:
All Genders
21-75 years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of this study is to compare the effect of sodium bicarbonate versus no sodium bicarbonate treatment on urinary ammonia levels and urinary transforming growth factor-beta1 (TGF-beta1) excre...
Detailed Description
Renal allograft survival ten years after transplant is only about 50%. In people with non-transplant chronic kidney disease (CKD), sodium bicarbonate treatment seems to delay progressive decline in ki...
Eligibility Criteria
Inclusion
- Renal transplant recipients
- Age 21-75 years
- Six months since the time of the most recent transplant
- Serum bicarbonate 20-28mM on the two most recent serum measures with the last six months
- Stable creatinine
Exclusion
- Systolic blood pressure \> 140mmHg
- Diastolic blood pressure \> 90mmHg
- Known ejection fraction \<50%
- Clinical diagnosis of heart failure
- Use of \>3 antihypertensive agents
- \> 1+ edema
- Use of alkali in the preceding 3 months
- History of noncompliance with clinic visits
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT01225796
Start Date
November 1 2010
End Date
November 1 2012
Last Update
April 6 2016
Active Locations (1)
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1
University of Utah
Salt Lake City, Utah, United States, 84132