Status:
UNKNOWN
Investigation of the Suburothelial Myofibroblast Network and of Smooth Muscle Function and Control in the Human Urinary Outflow Tract
Lead Sponsor:
Ludwig-Maximilians - University of Munich
Conditions:
Incontinence, Overactive Bladder, Stress Urinary Incontinence
Eligibility:
All Genders
18+ years
Brief Summary
The aim is to find out if adreno-muscarinic synergy is present also in human tissues of the urinary outflow tract that have a dual adrenergic-muscarinic receptor fitting. To further characterise morph...
Eligibility Criteria
Inclusion
- Tissue will be collected from the operation theatre only after having obtained the patient´s consent and in strictest accordance with histopathological requirements, i.e. after assessment of resection margins. It might be necessary to retrieve the tissue from the pathologist after first pathological assessment is completed. Tissue will be placed in Tyrode´s solution, gassed with 95 % O2 and 5 % CO2, for functional and RT-PCR or Western blot experiments, or in OCT (optimal cutting temperature) compound, snap-frozen in liquid nitrogen, and stored in a -80°C freezer until cutting for immunohistochemical experiments.
Exclusion
- None.
Key Trial Info
Start Date :
January 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01227447
Start Date
January 1 2010
Last Update
March 5 2012
Active Locations (1)
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1
Ludwig Maximilians University Munich, Dep Urology
Munich, Germany, 81377