Status:
COMPLETED
Neural Response to Eating and Weight Status
Lead Sponsor:
University of Pennsylvania
Conditions:
Obesity
Eligibility:
FEMALE
18+ years
Brief Summary
This study will compare brain and hormone responses to food images (and food) in women who undergo: (1) gastric bypass surgery; (2) principally restrictive surgery (laparoscopic adjustable gastric ban...
Detailed Description
We hypothesize that RYGB-treated patients will exhibit greater reductions (from baseline) in BOLD response in areas associated with homeostatic and hedonic eating than will both LAGB/LSG and control p...
Eligibility Criteria
Inclusion
- Women
- Over 18 years old
- BMI of 40 kg/ m2 (or 35 kg/m2 in the presence of significant weight-related comorbidities, including established coronary artery disease, established peripheral arterial disease, symptomatic carotid artery disease, sleep apnea, metabolic syndrome, cardiomyopathy, hypertension, and debilitating joint pain).
- Non-surgical group must be willing to remain weight stable and not seek weight loss (i.e., defined as remaining within 5% of baseline weight).
Exclusion
- Weight \> 350 pounds the maximum weight that can be accommodated in the scanner); supine abdominal width (with arms folded above) \> 60 cm or sagittal diameter \> 50 cm (i.e., these are the maximum dimensions that can be accommodated in the scanner)
- Pregnancy or lactation
- Type 1 or type 2 diabetes
- Severe major depression or other psychiatric disorder that significantly interferes with daily living
- Substance use disorder (current or in remission 1 year)
- Current use of nicotine or any illicit drug
- Presence or history of orthopedic circumstances, metallic inserts, pacemaker, claustrophobia, or other conditions that may interfere with magnetic resonance imaging
- Use of weight loss medications or other agents known to affect body weight or blood glucose (e.g., glucocorticoids, second-generation antipsychotic medications)
- Lack of capacity to provide informed consent
- Non-surgical participants interested in losing weight in the next 2 years
- Plans to relocate from the area within 2 years
- Principal Investigator discretion
Key Trial Info
Start Date :
April 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT01228097
Start Date
April 1 2010
End Date
January 1 2015
Last Update
March 10 2015
Active Locations (1)
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1
University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, United States, 19104