Status:
UNKNOWN
Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients.
Lead Sponsor:
University Hospital, Antwerp
Conditions:
Acute Kidney Injury
Hemodialysis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the feasibility, safety and efficacy of hemodialysis with unfractionated heparin compared to hemodialysis with Citrasate in Critically Ill Patients.
Detailed Description
Objective : To compare the feasibility, safety and efficacy of Sustained Low Efficiency Daily Hemodialysis (SLEDD) using regional anticoagulation with Citrasate® compared to systemic anticoagulation w...
Eligibility Criteria
Inclusion
- Need for hemodialysis in the ICU for at least one treatment
- No prior hemodialysis treatment in the ICU except continuous renal replacement therapy
Exclusion
- Need for systemic anticoagulation with unfractionated or fractionated heparin, oral anticoagulants or intravenous anti-aggregants for other reasons
- Need for continued thrombolysis therapy within the 6 hours before inclusion
- Need for continued treatment with activated protein C (drotrecogin alfa) within the 12 hours before inclusion
- Need for continued treatment with intravenous anti-aggregants (abciximab, eptifabide) within 12 hours before inclusion
- Liver failure (acute and acute-on-chronic)
- Confirmed or suspected Heparin Induced Thrombocytopenia (HIT)
- Heparin allergies
- Severe uncorrected hypocalcemia (ionized calcium \< 0,8 mmol/l)
- Refusal of informed consent
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2013
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT01228292
Start Date
January 1 2011
End Date
January 1 2013
Last Update
October 26 2010
Active Locations (1)
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1
Critical Care Department of the Antwerp University Hospital, Belgium
Edegem, Edegem, Belgium, 2650