Status:
COMPLETED
Assessment of Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion
Lead Sponsor:
Fondazione IRCCS Policlinico San Matteo di Pavia
Conditions:
Anesthesia
Surgery
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
The aim of the study is the assessment of the systemic absorption of local anesthetics during continuous epidural infusion for postoperative pain control.
Detailed Description
In literature the systemic toxicity of bupivacaine is widely demonstrated, like the minor toxicity of levobupivacaine and ropivacaine at the same anesthetic potency. The are actually no studies in hum...
Eligibility Criteria
Inclusion
- ASA I or ASA II
- Scheduled for major surgery
- written informed consent
Exclusion
- ASA III, IV
- Emergency surgery
- Recovery in intensive care unit after surgery
- habitual opioid consumption
- cognitive or mental alterations
- coagulopathy
- piastrinemia \< 100.000/mm3
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
181 Patients enrolled
Trial Details
Trial ID
NCT01229241
Start Date
July 1 2005
End Date
July 1 2011
Last Update
January 20 2012
Active Locations (2)
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1
IRCCS Policlinico San Matteo
Pavia, Lombardy, Italy, 27100
2
Unità Operativa di Anestesia e Rianimazione - Azienda Ospedaliera San Gerardo
Monza, Italy, 20052