Status:
COMPLETED
Isotopic Imaging for Prodromal Alzheimer's Disease
Lead Sponsor:
Centre Hospitalier Universitaire de Nīmes
Conditions:
Alzheimer Disease
Eligibility:
All Genders
70+ years
Brief Summary
The primary objective of this study is to characterize cerebral metabolism modifications using 18F-FDG PET technology and perfusion with 99MTC-ECD SPECT in patients with prodromal Alzheimer's Disease ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for the group with memory problems:
- patient consulting for memory problems
- caucasian
- memory complaint is validated by a clinical evaluation
- cognitive performance is sufficiently well preserved so that a diagnostic of dementia cannot be made (according to the DSM-IV-R and NINCDS-ADRDA criteria) at the time of inclusion
- the patient speaks French
- presence of an informant
- accepts to sign consent
- Inclusion Criteria for the group without memory problems (reference population):
- at least four years of formal education
- patient consulting for memory problems
- memory problem reported by the patient is not validated by the consultation, nor by the battery of tests specified during screening
- presence of an informant
- Clinical Dementia Rating (CDR) = 0
- accepts to sign consent
- Exclusion Criteria:
- Instrumental Activities of Daily Living (IADL): at least two items \> 1
- Anticholinesterasic treatments and/or memantin before study inclusion
- major depressive syndrome, according to the Global Depressive Scale
- Known neurodegenerative disease or general disease or major physical problems that could interfere with cognitive functioning and testing
- Pathology that might lead to death in the short term (evolving cancer, non stable cardiopathy, hepatic, renal or respiratory insufficiency)
- contra-indications for MRI, PET or SPECT scans
- not affiliated with a social security regimen
Exclusion
Key Trial Info
Start Date :
February 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2016
Estimated Enrollment :
143 Patients enrolled
Trial Details
Trial ID
NCT01231295
Start Date
February 1 2011
End Date
September 1 2016
Last Update
February 1 2017
Active Locations (25)
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1
CHU d'Amiens - Hôpital Sud
Amiens, France, 80054
2
CHU d'Angers - Hôtel-Dieu
Angers, France, 49933
3
CHU de Besançon - Hôpital Jean Minjoz
Besançon, France, 25030
4
CHU de Bordeaux - Groupe Hospitalier Pellegrin
Bordeaux, France, 33076