Status:
UNKNOWN
The Effect of Exercise Training on Skeletal Muscle Metabolism in Peripheral Artery Disease (PAD)
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
American Heart Association
Joslin Diabetes Center
Conditions:
Claudication
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Specific Aim 1: To test the hypothesis that subjects with PAD and intermittent claudication have altered expression of genes that regulate skeletal muscle metabolism. Specific Aim 2: To test the hypo...
Eligibility Criteria
Inclusion
- claudication symptoms
- ABI ≤ 0.9 in the symptomatic leg
Exclusion
- diabetes
- impaired fasting glucose
- peripheral vascular intervention within the prior six months
- recent unstable angina
- myocardial infarction or stroke within the prior six months
- changes to their HMG-CoA reductase inhibitor (statin)within the past three months
- changes to pentoxifylline and/or cilostazol regimen within the past three months or anticipated to be necessary during the study
- are on Coumadin
- exercise limitations for reasons other than intermittent claudication (such as congestive heart failure, angina, chronic lung disease, or other disorders affecting the limb such as arthritis or neuropathy)
- rest pain or ulcers due to critical limb ischemia
- lower extremity amputation
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2014
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT01231360
Start Date
October 1 2010
End Date
June 1 2014
Last Update
February 22 2013
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115