Status:
TERMINATED
Efficacy of Topical Capsaicin Cream for Stable Angina
Lead Sponsor:
Neal Weintraub
Collaborating Sponsors:
University of Cincinnati
Conditions:
Stable Angina
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to test the hypothesis that application of topical capsaicin in patients with stable angina will result in improved exercise tolerance and reduced cardiac ischemia.
Detailed Description
Patients with stable angina on medical therapy who are capable of exercising on a treadmill and have an interpretable ECG for ischemia will be enrolled in the study, which entails performing two tread...
Eligibility Criteria
Inclusion
- \> or = 3 month history of chronic, stable, angina triggered by physical effort or mental/emotional stress
- documented stress-induced ST depression, reversible perfusion imaging, or wall motion abnormality or CAD \>50%
- Canadian Cardiovascular (CV) Class I-III
- Receiving medical therapy for \> or = 2 months
- Ability to perform Bruce Protocol treadmill test
- non-pregnant female
Exclusion
- unstable angina
- revasc within 2 months
- Myocardial infarction (MI) within 2 months
- congestive heart failure (CHF) hospitalization within 2 months
- New York Heart Association (NYHA) class III or IV
- left ventricular ejection fraction (LVEF) \< 25%
- abnormal ECG; Acute changes on ECG
- Currently receiving treatment with investigational drugs/devices
- Uncontrolled hypertension
- contraindication to exercise stress testing
- allergy to red peppers or capsaicin
- skin deformity, scar, or rash at application site
- abdominal surgery within 3 months
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT01231750
Start Date
October 1 2010
End Date
March 1 2012
Last Update
June 25 2015
Active Locations (1)
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1
University of Cincinnati Physicians, Inc
Cincinnati, Ohio, United States, 45219