Status:
WITHDRAWN
Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy
Lead Sponsor:
Pediatric Brain Tumor Consortium
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Brain and Central Nervous System Tumors
Eligibility:
All Genders
4-21 years
Phase:
NA
Brief Summary
RATIONALE: Studying samples of blood in the laboratory from patients receiving radiation therapy and chemotherapy may help doctors learn more about the effects of this treatment on cells. It may also ...
Detailed Description
OBJECTIVES: Primary * Evaluate the fraction of peripherally circulating T-regulatory cells (T\_regs) in pediatric patients with newly diagnosed medulloblastoma and compare it to the levels found in ...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria:
- Histologically confirmed posterior fossa tumor
- Newly diagnosed disease
- Medulloblastoma OR non-medulloblastoma (pilocytic astrocytoma, ependymoma, atypical rhabdoid tumor, or others)
- Scheduled to undergo craniotomy and tumor resection
- Chiari malformation
- Requires craniectomy for decompression
- No secondary decompression
- PATIENT CHARACTERISTICS:
- No unexplained febrile illness
- No active infection
- No autoimmune disorders such as inflammatory bowel disease, juvenile rheumatoid arthritis, or systemic lupus erythematosus
- No other immunosuppressive disorders (e.g., HIV infection)
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 24 2017
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01233479
Start Date
May 1 2010
End Date
August 24 2017
Last Update
April 1 2019
Active Locations (11)
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1
Childrens Hospital Los Angeles
Los Angeles, California, United States, 90027-0700
2
Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, United States, 94304
3
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010-2970
4
Children's Memorial Hospital - Chicago
Chicago, Illinois, United States, 60614